Correlation between mean lung density and lung function test in patients with chronic obstructive pulmonary disease by dual phase CT / 西安交通大学学报(医学版)

ABSTRACT

ABSTRACT Objective: To investigate the correlation between the biphasic mean lung density (MLD) measured by a computer-aided method and the pulmonary function test (PFT) in patients with chronic obstructive pulmonary disease (COPD). Methods: Sixty COPD patients diagnosed in The Affiliated Hospital of Yan'an University from June 2017 to June 2018 were retrospectively recruited. CT scans at the end of inspiratory phase and the end of expiratory phase were performed. MLD of the whole lung and individual lobes were measured by a three-dimensional method, and PFT was performed within one week. The correlation between MLD and PFT was analyzed. Results: We found a slight positive correlation between MLDin and PFT of the whole lung and each lung lobe (P<0.05). MLDex, MLDex-MLDin of the whole lung and each lung lobe showed moderate to high positive correlation with PFT (P<0.01), and MLDex/in of the whole lung and each lung lobe showed moderate to high negtive correlation with PFT (P<0.01). Conclusion: Quantitative measurement of mean lung density in COPD patients is correlated with lung function and MLDex/in of the whole lung shows the highest correlation.