Structure of calcium/calmodulin-dependent protein kinase type II and its role in nervous system / 解剖学报

ABSTRACT

Calcium (Ca2+) has long been recognized as a crucial intracellular messenger attaining stimuli specific cellular outcomes via localized signaling. Ca2; binding proteins, such as calmodulin (Ca.M) and its target proteins are key to Ca2;-dependent signaling events. Calcium/calmodulin-dependent protein kinase type II (CaMK II) is a highly abundant polymer enzyme comprising a significant fraction of total protein in mammalian forebrain and forming a major component of the postsynaptic density. In recent years, studies have shown that CaMK D contains four subtypes of a, (3, y and 8, in which CaMK II a and p are mainly expressed in nerve tissues and 7 and 6 are expressed in the whole body. They are essential for certain synaptic plasticity and memory consolidation processes, both in the central nervous system and in the excitability of the nervous system and in some neurological diseases. CaMK II may play an important role in the pathogenesis of some nervous system diseases. Previous studies have also shown that CaMK II 8 plays an important role in promoting neuronal survival. The structure of CaMK H and its role in nervous system and its relationship with related nervous system diseases will be reviewed.