Inhibitory action of docetaxel on the proliferation of HeLa and SiHa cells / 西安交通大学学报·英文版
Academic Journal of Xi'
;
an Jiaotong University;(4): 260-264, 2010.
Article
in Chinese
| WPRIM
| ID: wpr-844709
ABSTRACT
Objective:
To study the inhibitory action of docetaxel (DOC) on the proliferation of HeLa and SiHa cells.Methods:
Cell morphological changes were observed with inverted phase contrast microscope. MTT was adopted to test and calculate the cell inhibition ratio. Flow cytometry was used to detect cell cycle.Results:
DOC had an obvious concentration-dependent inhibitory effect on the proliferation of both HeLa and SiHa cells. The inhibition ratio of DOC on SiHa was significantly higher than that on HeLa (P<0.05). DOC blocked HeLa at G2/M phase. Under the effect of DOC, the cell cycle of SiHa was not changed much.Conclusion:
DOC has an obvious inhibitory action on both HeLa and SiHa cells, which shows a promising prospect of DOC in clinical treatment of cervical cancer.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Academic Journal of Xi'an Jiaotong University
Year:
2010
Type:
Article
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