Comparative study on ghrelin level change and its related factors in hypertensive elders with psychological distress / 西安交通大学学报·英文版
Academic Journal of Xi'
;
an Jiaotong University;(4): 192-197, 2010.
Article
in Chinese
| WPRIM
| ID: wpr-844724
ABSTRACT
Objective:
To investigate the change of plasma ghrelin level and explore the related factors of ghrelin alteration in elderly hypertensive patients with psychological distress.Methods:
A total of 300 elders, who were screened with Hamilton Anxiety Scale (HAMA), Hamilton Rating Scale for Depression (HAMD), and the Symptom Checklist-90 (SCL-90) for psychological stress and somato-psychological manifestations respectively, were divided into hypertension group (n = 148) and non-hypertension group (n = 152). Their blood samples were collected to measure the plasma level of ghrelin and total cortisol on the same day.Results:
The incidences of anxiety and depression were 27.7 % and 11.7 %, respectively, in all the enrolled elders. However, the rates of psychological distress, particularly anxiety, were significantly higher in the hypertensive elders than in the non-hypertensive ones (43.2 % vs. 12.5 %). Anxiety was positively related to the cortisol level but negatively related to the plasma ghrelin level, and the latter two were negatively correlated with each other.Conclusion:
Chronic increase of plasma cortisol induced by long-term anxiety can lead to the reduction of ghrelin level, which then adversely affects blood pressure in elders with psychological distress. Therefore, ghrelin might be a selective antihypertensive medicine for hypertensive elders with anxiety.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Academic Journal of Xi'an Jiaotong University
Year:
2010
Type:
Article
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