Significance of intensive glycemic control on early diabetic nephropathy patients with microalbuminuria / 西安交通大学学报·英文版

ABSTRACT

Objective: To investigate the therapeutic effect of intensive glycemic control on patients with early diabetic nephropathy. Methods: A total of 41 type 2 diabetes patients who developed microalbuminuria were divided into two groups randomly. Patients in Group A received intensive glycemic control and the blood glucose in Group B was regularly controlled. Glycemic monitoring and control were followed for 12 weeks to observe the changes of microalbuminuria in both groups; meanwhile the levels of serum lipids and coagulation indices were also recorded. Results: The urine albumin excretion rate (UAER) in Group A decreased significantly from (47.91±13.86)mg/24 h to (35.31±14.56)mg/24 h after 12 weeks (P0.05]. The decrease of triglyceride (TG) and low-density lipoprotein cholesterol (LDL cholesterol), and the increase of high-density lipoprotein cholesterol (HDL cholesterol) showed no significant differences (P>0.05). And the level of plasma fibrinogen (FIB) showed no significant decrease after 12 weeks, either (P>0.05). Conclusion: Intensive glycemic control reduces the level of microalbuminuria and may ameliorate the progression of early diabetic nephropathy.