Expression and role of Tie-2 in rectal carcinoma / 西安交通大学学报·英文版

ABSTRACT

Objective: To investigate the expression of Tie-2 in rectal carcinoma and its relationship with invasion and metastasis in rectal carcinoma. Materials S-P immunohistochemical assay was used to detect the expression of Tie-2 in 40 cases of rectal carcinoma and 10 cases of normal rectal tissues. Results: Tie-2 was mainly localized in the cytoplasm and nucleus of vascular endothelial cells in cancerous tissues and partly in the cytoplasm of some cancerous cells. The expression of Tie-2 in rectal carcinoma was significantly higher than that in normal rectal tissues (P0.05), but with lymphatic metastasis (P<0.05). Conclusion: Tie-2 plays a key role in carcinogenesis and lymph node metastasis of rectal carcinoma.