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Changes in firing rate and firing pattern of midbrain dopaminergic neurons after lesioning of the dorsal raphe nucleus by 5,7-drhydroxytryptamine in adult rats / 西安交通大学学报·英文版
Academic Journal of Xi&#39 ; an Jiaotong University;(4): 76-81, 2008.
Article in Zh | WPRIM | ID: wpr-844830
Responsible library: WPRO
ABSTRACT
Objective: To study the effect of serotonergic efferent projection of the dorsal raphe nucleus (DRN) on the activity of substantia nigra pars compacta (SNc) and ventral tegmenta area (VTA) dopaminergic neurons after lesioning of the DRN by the neurotoxin 5,7-drhydroxytryptamine (5,7-DHT) in rat. Methods: The changes in the firing rate and firing pattern of SNc and VTA dopaminergic neurons were observed with extracellular recording in control and the lesioned rats. Results: The results showed that the mean firing rates of the fast-firing dopaminergic neurons of the SNc in control and the lesioned rats were (5.34±0.13) Hz (n=23) and (7.13±0.49) Hz (n=37), respectively. The mean firing rate of the fast-firing dopaminergic neurons of the SNc in the lesioned rats was significantly increased when compared to that of control rats (P<0.01), while the mean firing rate of the slow-firing dopaminergic neurons of the SNc did not change. The mean firing rates of dopaminergic neurons of the VTA in control and the lesioned rats were (5.27±0.38) Hz (n=35) and (3.6±0.2) Hz (n=52), respectively. Lesioning of the DRN induced a significant decrease in the mean firing rate of dopaminergic neurons of the VTA. The firing pattern of SNc and VTA dopaminergic neurons changed towards a more bursting or irrgular firing after the lesioning. Conclusion: These data suggest that the serotonergic efferent projections of the DRN significantly affect the activity of SNc and VTA dopaminergic neurons.
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Full text: 1 Index: WPRIM Language: Zh Journal: Academic Journal of Xi&#39;an Jiaotong University Year: 2008 Type: Article
Full text: 1 Index: WPRIM Language: Zh Journal: Academic Journal of Xi&#39;an Jiaotong University Year: 2008 Type: Article