Characteristics of drug resistance and genotype of Mycobacterium tuberculosis in different regions of Qinghai province / 国际药学研究杂志

ABSTRACT

Objective: To explore the differences in drug resistance and genotypes of Mycobacterium tuberculosis(MTB) strains isolated from Xining city and agricultural and pastoral areas of Qinghai province, China, so as to provide reference for prevention and clinic treatment of tuberculosis in Qinghai province. Methods: The drug resistance of isolated 249 strains of MTB was tested by proportional method, the regional distribution characteristics and the relationship between drug resistance and spoligotyping geno-type were analyzed by statistical methods. Results: The total first-line drug resistance rate of 249 strains of MTB was 56.6%, and the total drug resistance rate in agricultural and pastoral areas(74.6%)was higher than that(50.0%)in Xining city(P<0.05). The multidrug resistance rate in agricultural and pastoral areas(49.3%)was higher than that(25.3%)in Xining(P<0.05). It was found that ofloxacin had the highest drug resistance rate both in Xining and rural areas. The dominant strain was Beijing genotype both in Xining city as well as the agricultural and pastoral areas. The multidrug resistance rate of Beijing genotype strains in Xining(21.2%)was lower than that of non-Beijing genotype strains(36.0%). The resistance rates of Beijing genotype strains to isoniazid(INH)and ethambutol (EMB)in rural area were higher than those of non-Beijing genotype strains(65.4%33.3% and 63.4%33.3%, respectively, both P< 0.05). Conclusion: The Beijing genotype MTB is the main epidemic strain in both Xining and agricultural or pastoral areas, and drug resistance of MTB is severe in rural areas.