Chitosan modified material and its application in hemostasis: research advances / 国际药学研究杂志

ABSTRACT

Chitosan(CS)is the product of chitin derived by removal of some acetyl groups, which is non-toxic, safe and biodegradable. It is easily obtainable and has wide application prospects. However, due to its intramolecular hydrogen bonding and spatial configuration of macromolecules, CS is not easily soluble in water and organic solvents, so its application is limited. For its extended application, CS is often modified or compounded with other materials. This article briefly summarizes the modification methods of CS, including acylation, etherification, alkylation, quaternization, graft copolymerization, etc., and introduces the application of CS composite materials in hemostasis.