Application progress in the charged aerosol detector / 国际药学研究杂志

ABSTRACT

In recent years, charged aerosol detector(CAD)has become a valuable tool for detecting substances with no ultraviolet absorption or with only end absorption. Its advantages inclucle broad linearity response range, high sensitivity and reproducibility, the signal response consistency independent of chemical structures, as well as the simply operable feature. This article briefly describes the working principle of CAD and introduces the application progress of the detector in the natural product and pharmaceutical detection as well as in the sugar, lipid, amino acid and surfactant analysis, so as to provide a reference for the liquid chromatographic analysis of non-volatile and semi-volatile compounds.