Synthetic progress towards natural products communesins / 国际药学研究杂志

ABSTRACT

Communesins are a class of alkaloids mainly from the marine-derived fungi belonging to the genus Penicillium. The communesins contain a unique, densely functional caged seven-ring system skeleton, with five stereogenic centers at least, of which two are the vicinal quaternary carbon centers. These structural features make the synthesis of these compounds extremely challenging. In addition, communesins have been known to have a variety of biological activities such as the insecticidal, cell proliferation inhibito ry and significant cytotoxic activities. At present, eight research groups have completed the total synthesis of several communesins, and reports on the skeleton synthesis have been published. This paper summarizes the chemical skeleton synthesis and total synthesis of communesins in a chronological order, so as to provide a reference for further studies on this class of natural compounds.