The effect of species difference in carboxylesterase on the drug metabolism / 国际药学研究杂志
Journal of International Pharmaceutical Research
;
(6): 91-96, 2020.
Article
in Chinese
| WPRIM
| ID: wpr-845203
ABSTRACT
Carboxylesterase(CES), the most abundant hydrolase in humans and animals, participates in the metabolism of various endogenous and exogenous compounds and drugs. The distribution and activity of CES have obvious species differences in hu mans and animals, which are closely related to the pharmacokinetics(PK), pharmacodynamics(PD)and toxic side effect of drugs. Therefore, this paper summarizes the effects of the difference in the classification, distribution, induction and inhibition of CES as well as the effects of species difference in plasma, liver, small intestine and skin on the metabolism of ester prodrugs, so as to provide a reference for the correct selection of experimental animals in preclinical studies of new drugs to accurately predict the clinical PK, PD and toxicological effects.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Journal of International Pharmaceutical Research
Year:
2020
Type:
Article
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