Small molecule regulator against circadian rhythm disorder:research advances / 国际药学研究杂志

ABSTRACT

The circadian rhythm maintains various physiological functions of our body, and regulates the body to cope with the external environment. The disorder in the circadian rhythm could produce harmful effects and increase the risk of diseases. A grow ing research has shown that many small molecule regulators could target the circadian rhythm system, and many new techniques and strategies, including the high-throughput screening technique, have been used in the discovery and investigation of new small mole cule regulators of the circadian rhythm system. In this review, we introduce basic components and molecular mechanisms of the circa dian rhythm system, summarize research progresses in the small molecule regulators, explain the relationship between various chronic diseases and circadian clocks, and discuss potential applications of the small molecule modulators in the treatment of circadian rhythm-related diseases.