Chemical constituents of traditional Chinese materia medica for alleviating renal damage of paracetamol:research advances / 国际药学研究杂志

ABSTRACT

Paracetamol (acetaminophen, APAP)is one of the commonly used analgesic, antipyretic and anti-inflammatory drugs, but it can cause acute kidney injury(AKI)or even acute renal failure due to blind, large, combined or long-term use. The mechanism reseach on the APAP-induced nephrotoxicity is mainly focused on the formation of metabolic toxic substances, oxidative stress, inflammatory response, mitochondrial dysfunction, endoplasmic reticulum stress(ERS), and changes in glomerular hemody namics. This paper summarizes the toxicity mechanism of APAP-induced AKI(APAP-AKI), and the research progress in the protec tive effect of active ingredients of traditional Chinese materia medicas(TCMM)on APAP-AKI, including polyphenols, flavonoids, quinones, terpenoids, amino acids and other type substances, with an aim to clarify the key mechanisms and signaling pathways of APAP-AKI and to provide reference for the development of drugs for the prevention and treatment of APAP-AKI.