Research progress of natural marine product macrosphelides / 国际药学研究杂志
Journal of International Pharmaceutical Research
;
(6): 899-911, 2019.
Article
in Chinese
| WPRIM
| ID: wpr-845220
ABSTRACT
This paper summarizes the natural macroephelides,including the preparation of three key segments and the synthesis of 16-or 15-membered macrolactone skeleton by the ring-closing metathesis(RCM)strategy. It also summarizes the synthetic approaches to macrosphelide derivatives,including the common pharmaceutical chemistry methods,such as the ring size modification,the modification of lateral groups on the macro ring,and the combinatorial chemistry approach. Additionally,a brief introduction of structure-activity relationships is given for related compounds.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Journal of International Pharmaceutical Research
Year:
2019
Type:
Article
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