mRNA vaccine delivery system based on liposome: research advances / 国际药学研究杂志

ABSTRACT

mRNA vaccines are a new class of nucleic acid vaccines. Compared with DNA vaccines, mRNA vaccines do not need to enter the nucleus, and there is no risk of integration into the genome, which makes them relatively safer. However, the poor stability of mRNA vaccines and the facile degradation by nuclease in vitro and in vivo are the bottlenecks restricting its development. Therefore, mRNA vaccines need to have a suitable delivery vehicle to deliver them to the body in order to have a better immune effect. Currently, mRNA delivery vectors include viral vectors and non-viral vectors. In this paper, a brief overview of non-viral vector liposome is presented, mainly focusing on the mRNA vaccines, liposome, endosomal escape and enhancing liposome delivery, and the research prospects of mRNA and liposome delivery vectors are also commented.