Clinical application and stability of hydromorphone in an implantable imfusion system: Research advances / 国际药学研究杂志

ABSTRACT

Hydromorphone (HM), appeared in the Chinese market in 2013 is a more potent opioid analgesic than morphine and is used for moderate to severe pain. Micro-invasive drug administration methods,including continuous infusion and patientcontrolled analgesia(PCA), will provide hopes for controlling the outbreak of pain and improving patients' satisfaction. At present, hydromorphone is the most commonly used drug for the treatment of acute pain, chronic pain and cancer pain. However, we should also consider the stability and compatibility of hydromorphone in the implantable infusion system that is most commonly used in these patients. The purpose of this paper is to review the clinical application and stability (changes in color, pH and concentration) of hydromorphone in different infusion systems so as to provide the basis of rational clinical application.