Therapeutics of enterovirus 71 infection: Research advances / 国际药学研究杂志

ABSTRACT

Enterovirus 71 (EV71) is the main pathogen of severe hand-foot-mouth disease. As the characteristics and the pathological mechanism of EV71 gradually become clear, the therapeutic strategies of EV71 infection are clarified. Acting on specific target can directly interfere the process of EV71 infection, while regulating the host immune can clean the virus, ease inflammation and protect uninfected cells. In addition, some cytokines like interferon with both broad-spectrum antiviral function and immune regulation are used in clinical. In addition, drug combination could enhance the antiviral effect and reduce toxicity and drug resistance. At present, most of the therapeutics are still in pre-clinical phase, while only a few are in clinical application. This article reviews the different types of EV71 infection treatment strategies and methods recently reported, in order to provide help for further research on anti-EV71 infection.