Active derivatives based on the resveratrol scaffold: Research advances / 国际药学研究杂志

ABSTRACT

Natural product resveratrol has antioxidation, cardiovascular protection and many other useful biological activities. In recent years, many researchers have paid more and more attention to it. However it cannot be used as candidate for the development of new drug due to its poor druggability. Novel resveratrol derivates with improved water solubility and highly potent biological activity could be obtained by chemical modifying of chemical structure of resveratrol. Researches have shown that resveratrol derivatives exhibit many kinds of attractive activities, including antitumor, reducing blood fat, antiviral, anti-neurodegenerative diseases and so on, which makes them could be used as leads for the further developing of new drugs. This review discusses the development of novel resveratrol derivatives by chemical modification in recent years.