Induced pluripotent stem cells: Powerful tools for the study of neurodegenerative diseases and clinical therapy / 国际药学研究杂志

ABSTRACT

In recent years, continuous progress has been made in the induced pluripotent stem cells (iPSC) research. iPSC can differentiate into many kinds of expected neural cells to treat nervous system diseases which lack of neural cells, and play relevant functional roles. Since the iPSC are generated from the somatic cells, they do not have the problems of the ethics and immune rejections and open the windows for their clinical applications to study the mechanisms, drug screening and autotransplantation therapy of the human diseases. Here we reviewe the recent research and application of iPSC on some neurodegenerative diseases, such as Parkinson's disease (PD), Alzheimer's disease (AD), spinal muscular atrophy (SMA), amyotrophic lateral sclerosis (ALC) and Huntington's disease (HD).