Translocator protein 18ku: A potential new therapeutic target for anxiety in the future / 国际药学研究杂志

ABSTRACT

Anxiety is one of the psychiatric disorders. However, the pathogenesis of anxiety is still uncertain. Translocator protein (18×103, 18ku) (TSPO) ligands have been proved useful in the treatment of neurological and psychiatric disorders, especially anxiety. TSPO Ligands are promising candidates for fast-acting anxiolytic drugs with less severe side effects than benzodiazepines. This review summaries TSPO molecular structure, distribution, and its function of treating anxiety and illustrates the advantage of TSPO ligands in treating anxiety and its application prospect.