Research advances in synthesis of lesinurad / 国际药学研究杂志

ABSTRACT

Lesinurad (RDEA 594), discovered by Ardea Biosciences, is a new drug used for the treatment of gout. RDEA594 could increase the excretion of uric acid to reduce uric acid levels by inhibiting the uric acid salt transport protein 1 (URAT1). In this essay, we summarize synthetic methods of lesinurad reported in recent years, evaluate and analyze them briefly, aiming to lay a foundation for lesinurad synthesis process to achieve industrialization.