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Effect of XuanHuSuoSan and its disassembled prescriptions on dissolution of psoralen and isopsoralen / 国际药学研究杂志
Journal of International Pharmaceutical Research ; (6): 359-364, 2016.
Article in Chinese | WPRIM | ID: wpr-845595
ABSTRACT
Objective To investigate the effect of XuanHuSuoSan and its disassembled prescriptions on dissolution of psoralen and isopsoralen. Methods The dissolution of psoralen and isopsoralen in XuanHuSuoSan and its disassembled prescriptions were determined by HPLC, using ES Industries Epic Polar C18 column (250 mm×4.6 mm, 5 μm) with methanol and water (55 45) as mobile phase at 25 °C with a flow rate of 1.0 ml/min and detection wavelength of 246 nm. Results The dissolution of psoralen and isopsoralen had great changes among XuanHuSuoSan and its disassembled prescriptions, and the analysis of variance and SNK showed that there were significant differences among XuanHuSuoSan and its disassembled prescriptions (P < 0.05). Conclusion Radix Angelicae Sinensis and Radix Achyranthis Bidentatae are helpful to the dissolution of psoralen and isopsoralen from Fructus Psoraleae, while Rhizoma Corydalis can inhibit the dissolution of psoralen and isopsoralen.

Full text: Available Index: WPRIM (Western Pacific) Language: Chinese Journal: Journal of International Pharmaceutical Research Year: 2016 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Language: Chinese Journal: Journal of International Pharmaceutical Research Year: 2016 Type: Article