Specific molecular probes in early diagnosis and efficacy monitoring for Alzheimer’s disease: Research advances / 国际药学研究杂志

ABSTRACT

Alzheimer’s disease AD is the general type of senile dementia, posing a serious harm to the health of the elderly. Making an accurate and reliable diagnosis of AD at the earliest disease stages and evaluating the efficacy of drug in the course of drug treatment of AD is challenging and has become increasingly important. AD is characterized by early neuropathological senile plaque SP deposits and intracellular neurofibrillary tangles NFT in the brain. The studies of specific molecular probes targeted amyloid β Aβ and tau profein play an important role in the early diagnosis, classification of severity and efficacy monitoring of AD.Therefore, many research groups have focused on developing the high specific molecular probes of positron emission tomography PET imaging. In this article, we review the progress and clinical applications of the specific molecular probes of PET imaging in AD.