Application of ultrasonography in animal models of non-alcoholic fatty liver disease / 国际药学研究杂志

ABSTRACT

The high prevalence of non-alcoholic fatty liver disease (NAFLD) all around the world is a great threat which cannot be ignored. It shows urgent need for the appropriate methods of NAFLD diagnosis because of the broad spectrum of hepatic derangements and the undetectable characteristic in the early stage of this disease. Ultrasonic diagnosis for NAFLD is widely used in clinic clue to its advantages such as low cost, weak radiation and good compliance for patients. For the studies in animal models, the pathological progression of NAFLD can be evaluated by a variety of noninvasive ultrasonic methods recently. To improve the convenience, accuracy and reliability of the estimation of NAFLD progression in animal models, the applications and the principles of the ultrasonic technics are introduced. Diverse qualitative and semi-quantitative methods for animal NAFLD detection are reviewed.