Metabolic changes detected by1H NMR spectroscopy in the hippocampus of acute brain injury rats / 国际药学研究杂志

ABSTRACT

Objective To reveal the alterations of metabolic profiles by detecting changes in hippocampus1H NMR spectrin acute brain injury (ABI) rats. Methods The model of ABI was achieved by trauma, and 2 hours after modeling, the hippocampus samples were collected for NMR analysis. Results Compared to age-matched control rats, the ABI rats exhibited markedly different metabolic profiles, which showed significant changes in glutamate (P<0.01), taurine(5<0.05), myo-inositol (P< 0.05), and glutamine (P<0.05). Conclusion The metabonomics results suggest that amino acid metabolism is disordered when ABI occurs. This study provides clues for further understanding to cure ABI.