Drug therapy of multiple sclerosis: Research advances / 国际药学研究杂志

ABSTRACT

Multiple sclerosis (MS) is an autoimmune disease characterized by the immune-mediated demyelination of the central nervous system (CNS). There are still no disease-modifying therapeutics to cure MS per se, all patients need drugs to control their diseases. Most drugs in clinic target the immune system. New therapeutic strategies have evolved that specifically target the neurode-generative aspect of MS. Remyelinating agents are actively under investigation, and may yield novel strategies to increase neuronal functionality and survival in the coming years. In this review, we mainly describe the administration, mechanism of action, safety and efficacy of dugs currently approved for MS therapy. We also briefly introduce the new drugs for the treatment of MS currently under investigation.