Methods for target identification of bioactive compounds / 国际药学研究杂志

ABSTRACT

Target identification of bioactive compounds is one of the key issues in chemical biology and drug discovery. With the development of science technology, a variety of methods and technologies for target identification have been reported. They can be fundamentally categorized into two approaches: the direct method based on affinity chromatography which is mainly to detect the combination of drug and targets, and the indirect one which is mainly to predict the drug target and action mechanism by physiological reaction and biochemical marker. This review aims to describe the two approaches for target identification.