Cytochrome P450 2A5/2A6 and their gene expression regulation: Research advances / 国际药学研究杂志

ABSTRACT

In the cytochrome P450 superfamily, the murine hepatic cytochrome P450 2A5 (CYP2A5) and its human orthologue CYP2A6 catalyze the metabolism of various endogenous and exogenous compounds including steroid hormone, bilirubin and procarcinogens such as nitrosamines and aflatoxin B1. Genetic polymorphism of CYP2A6 can result in the individual differences of xenobiotic metabolism. Unlike the most other CYPs, CYP2A5/CYP2A6 are induced under pathological conditions of liver injury induced by xenobiotics, hepatitis and liver neoplasm. This article provides an overview of the structures, distribution and biological characteristics of CYP2A5/CYP2A6 and subsequently summarizes their gene regulation mechanisms.