Protective effect of olvanil against sulfur mustard-induced cutaneous injury / 国际药学研究杂志

ABSTRACT

Objective: To study the protective effects of olvanil on sulfur mustard (SM)-induced cutaneous injury. Methods: To establish mouse ear model of SM-induced cutaneous injury, KM mice right ears were exposed to 5 μl of 32 g/L or 128 g/LSM, respectively. Then we evaluated the protective effect of olvanil against SM-induced cutaneous injury with these two concentrations. For mice exposed to 32 g/L SM, olvanil (0.125, 0.25 and 0.5 mg/ear, topically) or indometacin (indomethacin, 10 mg/kg, po) were administrated 20 min or 30 min before SM exposure, respectively. After 24 h SM exposure, ear tissue was harvested and weighted, and the histopathological analysis was conducted. Similarly, for mice exposed to 128 g/L SM, olvanil (0.25 mg/ear, topically) or indomethacin (10 mg/kg, po) were administrated, and ear tissue was harvested and weighted. Results: Olvanil significantly inhibited 32 g/L SM-induced ear edema, cutaneous inflammation and necrosis, while no influence were observed on 128 g/L SM-induced cutaneous injury. Conclusion: Olvanil shows remarkable protective effect on cutaneous injury induced by SM of low concentration.