Research advance in cGAS-STING pathway: A pathway unlock the anti-HIV function of immune system / 国际药学研究杂志
Journal of International Pharmaceutical Research
;
(6): 528-532, 2014.
Article
in Chinese
| WPRIM
| ID: wpr-845794
ABSTRACT
Stimulator of interferon genes(STING) are important adaptor proteins in innate immune-related signal pathway. The upstream protein,cyclic guanosine monophosphate-adenosine monophosphate synthase(cGAS), is cytosolic DNA sensor. Detection of cytosolic DNA, cGAS-STING pathway can be activated and subsequently activate the type I interferon(IFN) antiviral response. Recent studies indicated that retroviruses especially HIV can activate the host innate immune system through cGAS-STING pathway and trigger robust immune response. In this review, we briefly describe the mechanism of innate immune activated by the newly discovered cGAS-STING pathway and highlight recent progress in STING agonist.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Journal of International Pharmaceutical Research
Year:
2014
Type:
Article
Similar
MEDLINE
...
LILACS
LIS