Anti-Tumor mechanisms of microtubule inhibitors / 国际药学研究杂志

ABSTRACT

Microtubules are a type of dynamic filamentous cytoskeletal protein, and a major component of centrosome. The regular dynamic changes in microtubules are the guarantees of mitosis. Microtubule inhibitors can promote or inhibit tubulin assembly, interfere cell mitosis and the normal structure and function of the spindle, resulting in the inhibition of cell proliferation and tumor specific therapeutic effect. Microtubule inhibitors, targeting different sites, are the key components of chemotherapeutic regiments for various solid tumors, and dozens of microbule inhibitors are already available in market or under clinical study. Including a brief description of the progress in paclitaxel, vinblastine and colchicine, this review systematically introduces the mechanism of a class of microtubule inhibitors.