Preparation method for in vivo metabolites of chemical constituents from traditional Chinese medicines / 国际药学研究杂志
Journal of International Pharmaceutical Research
;
(6): 711-720, 2013.
Article
in Chinese
| WPRIM
| ID: wpr-845853
ABSTRACT
Traditional Chinese medicines(TCM) are taken orally in most cases, and their chemical constituents generally have low blood concentrations and poor oral bioavailabilities. The absorbed chemical constituents of TCM, especially the in vivo biotransformed products might play an important role in explaining the effectiveness, and even the toxicities and side effects of TCM. Up to now, most of the studies on the in vivo metabolites of TCM constituents are still limited to structural identification, and only a few researches on the bioactivities and toxicities of the metabolites have been carried out since they are not easy to obtain. Therefore, the preparation of in vivo metabolites is necessary for deeply investigating how and why TCM show the effectiveness or toxicity. Based on the studies of our group on the metabolism of TCM bioactive compounds in recent years, the preparation methods for in vivo metabolites are summarized, which might be helpful for the study of metabolism of TCM.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Journal of International Pharmaceutical Research
Year:
2013
Type:
Article
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