Mechanism of JAK/STAT signal pathway and notch signaling crosstalking in the proliferation and differentiation of neural stem cells / 国际药学研究杂志

ABSTRACT

JAK/STAT is a pleiotropic signal transduction pathway with functions of regulating proliferation, differentiation and apoptosis in the cell. Recent research has shown that it plays an important role in embryonic development, brain tumors, cerebral ischemia and neural stem cell(NSC) proliferation process after brain injuries. Notch signaling pathway exists in all known animal cells, and it is a classic signaling pathway in the regulation of NSC proliferation and differentiation. Under the guidance of the network pharmacology, this article casts light on the crosstalk between JAK/STAT and Notch signal pathway in NSC proliferation, with the aim to provide basic theoretical supports in the research of drugs with the effectiveness of neuroprotection and NSC regulation after cerebral ischemia.