Development of functional epitope and neutralizing antibody of variola virus / 国际药学研究杂志

ABSTRACT

Smallpox is a deadly infectious disease caused by the variola virus with very high mortality rate. It had caused many global prevalences and greatly threatened human health in history. With the global promotion of vaccination, smallpox was declared to be extirpated in 1980. However, in recent years, because of vaccination intermittent, nature orthopox virus recombination or mutation, andthepotentialth eatofbiote o ism smalpoxhasbeenmentionedandt eatedse iouslyagain.Atp esent themainwaysofp eventing or treating smaUpox include vaccination, chemical drugs, neutralizing antibodies, and clinical symptomatic therapies. In this article, we review the functional epitope and neutralizing antibody research progress of the variola virus.