Progress in agmatine inhibiting opioid dependence / 国际药学研究杂志
Journal of International Pharmaceutical Research
;
(6): 401-407, 2010.
Article
in Chinese
| WPRIM
| ID: wpr-845916
ABSTRACT
Opioid addiction, also termed opioid dependence, is a chronic, relapsing disorder in brain, which induces a series of severe problems in the aspects of society, economy and public health. Because the neurobiological mechanisms of opioid dependence haven't been clarified, it lacks effective medical interventions. Researches on opioid dependence are focusing on clarifying its neurobiological mechanisms and discovering effective anti-relapse drugs. Agmatine is a candidate for neurotransmitter or neuromodulator, and considered as an endogenous ligand for imidazoline receptors. Based on our previous work, its pharmacological characteristics and possible mechanisms of agmatine inhibiting opioid dependence were reviewed.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Journal of International Pharmaceutical Research
Year:
2010
Type:
Article
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