Neurokinin-1 receptor antagonists: Research advances / 国际药学研究杂志

ABSTRACT

Substance P is one of the most important neurotransmitter in the nervous system. It plays an important role in the pathological process of many diseases through combineing with its receptors, for example, neurokinin-1 receptor (NKIR). The antagonists of NK1R (NK1RA) that are widely used in recent clinical treatments can not only relieve deppression and anxiety, but also have good antiemetic effects on chemotherapy-induced nausea and vomiting. In this review, the relevant study results in this field in recent years are described.