Determination of isosorbide 5-mononitrate in biological specimen by chromatography: Research advances / 国际药学研究杂志

ABSTRACT

It is difficult to est isosorbide 5-mononitrate in biological specimen due to its unsignificant UV absorption and thermal instability. Therefore, uarious methods such as HPLC, GC-ECD, GC-MS and HPLC-MS/MS were established to meet the needs of assay sensitivity and specificity. Research progress in the chromatography is reviewed in this paper.