Studies on antiestrogen compounds and their structure-activity relationships / 国际药学研究杂志

ABSTRACT

Antiestrogens have been proven to be highly effective in the treatment of estrogen receptor-dependent breast cancer. According to the mechanism, antiestrogen compounds were mainly categorized as selective estrogen receptor modulators (SERM) and pure antiestrogens, which structurally include estradiol derivatives, triphenylethylenes, benzo heterocyclic and polyphenol of natural compounds. The research advances on the antiestrogen compounds and their structure-activity relationships are reviewed.