CC chemokine receptor 4 and its inhibitors: Research advances / 国际药学研究杂志

ABSTRACT

CC chemokine receptor 4 (CCR4) , a member of G protein coupled receptor family, is consisted of a polypeptide chain containing seven-transmembrane domains and expressed on various cells and tissues. CCR4 can mediate nflammatory reaction by nteracting with ts ligands such as CCL17,CCL22 and CKLF1,which especially plays an mportant role n occurrence and development of asthma, thus it could be a potential target for treating nflammatory diseases, especially for asthma. In this paper,the research progress of CCR4 and ts inhibitors is summarized.