A Case of Improved Refractory Uveitis in Behcet's Disease after Infliximab Therapy / 대한류마티스학회지
The Journal of the Korean Rheumatism Association
;
: 320-323, 2005.
Article
in Korean
| WPRIM
| ID: wpr-84599
ABSTRACT
Behcet's disease is a multisystemic, chronic relapsing inflammatory disease characterized by vasculitides, mucocutaneous lesions, thrombophlebitis, arthritis. Among them, the ocular involvement is usual (50~70%) and the most serious morbidity is blindness (20~25% of those of affected). Immunosuppressive treatment is currently the main therapy in chronic relapsing uveitis, but many patients experience recurrent sight-threatening uveitis. T lymphocytes play an important role in the pathogenesis of uveitis by releasing cytokines such as tumor necrosis factor (TNF) alpha. There are some reports that the anti-TNFalpha treatment is effective in refractory Behcet's uveitis, but it has not been reported in Korea. We report a case of refractory uveitis in Behcet's disease which is improved after anti-TNFalpha therapy.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Arthritis
/
Thrombophlebitis
/
Uveitis
/
Vasculitis
/
T-Lymphocytes
/
Blindness
/
Cytokines
/
Tumor Necrosis Factor-alpha
/
Infliximab
/
Korea
Limits:
Humans
Country/Region as subject:
Asia
Language:
Korean
Journal:
The Journal of the Korean Rheumatism Association
Year:
2005
Type:
Article
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