Clinical efficacy evaluation and potential mechanism of Huanglian Ejiao Decoction in treatment of type 2 diabetes mellitus by Meta-analysis associated network pharmacology / 中草药

ABSTRACT

Objective: To evaluate the clinical efficacy of Huanglian Ejiao Decoction and explore its mechanism in the treatment of type 2 diabetes (T2DM) based on Meta-analysis and network pharmacology technology. Methods: Firstly, CNKI, VIP, Wanfang, PubMed, the Cochrane Library, and Web of Science were used to find randomized controlled trials of Huanglian Ejiao Decoction for T2DM until May 2020. The included literatures were evaluated according to the Cochrane risk bias assessment tool, and the Review Manager software was used for quantitative synthesis. The chemical components and its targets of Huanglian Ejiao Decoction were screened based on network pharmacology. Common targets were obtained after taking the intersection with T2DM targets. The bioinformatics technology was used to annotate key pathways, and the potential mechanism of Huanglian Ejiao Decoction was explored in the treatment of T2DM. Results: A total of 15 RCTs were selected which included 1 254 patients. Compared with the conventional treatment of western medicine, Huanglian Ejiao Decoction combined with western medicine had a more satisfactory clinical effect, stronger hypoglycemic and hypolipidemic effect. Through network pharmacology methods, 258 chemical components and 985 targets were obtained from online databases. There were 60 components, 121 targets, and 181 pathways closely related to the treatment of T2DM, mainly involving AGE-RAGE signaling pathway in diabetic complications, HIF-1 signaling pathway, MAPK signaling pathway, insulin resistance, etc. Conclusion According to the existing research, the conventional treatment of western medicine combined with Huanglian Ejiao Decoction can increase the clinical efficacy of T2DM and have better hypoglycemic and hypolipidemic action. T2DM can be cured by improving insulin resistance, reducing inflammation, mitigating oxidative stress and other treatments.