Meta analysis of clinical study on lumbago and leg pain treated by Yaotongning Capsule / 中草药

ABSTRACT

Objective: To systematic evaluate the efficacy and safety of Yaotongning Capsule in the treatment of lumbago and leg pain. Methods: The databases of CNKI, VIP, Wanfang and Chinese science citation were searched by computer, and the randomized controlled trials of Yaotongning Capsule in the treatment of lumbago and leg pain were collected. Two researchers independently selected literatures, entered data, and evaluated the quality of literature methodology. Review Manager 5.3 software was used for Meta analysis. Results: This study included 11 RCTs, 1 200 patients, 599 cases in Yaotongning group and 601 cases in control group. Meta analysis showed that the effective rate of Yaotongning Capsule in the treatment of lumbocrural pain was better than that of the control group (OR = 4.13, 95% CI [2.90, 5.88]), P < 0.000 01; The improvement of VAS pain score of Yaotongning Capsule was better than that of the control group (SMD = -1.22, 95% CI [-1.71, -0.73]), P < 0.000 01, (SMD = -2.09, 95% CI [-2.14, -2.04]). The improvement of JOA function score was better than that of the control group (SMD = 6.78, 95% CI [5.21, 8.26]), P<0.000 01, the difference was statistically significant. Conclusion: Yaotongning Capsule can effectively improve the lumbar activity function and clinical symptoms of patients with lumbocrural pain, and the degree of pain relief is positively correlated with the course of treatment and dose. However, the included sample size and observation indicators may lead to bias. It is expected that more researchers can conduct multi center, large sample, scientific and complete research to evaluate the efficacy and safety of Yaotongning Capsule in the treatment of lumbocrural pain.