Association between Ischemic Stroke and Vascular Shear Stress in the Carotid Artery
Journal of Clinical Neurology
;
: 133-139, 2014.
Article
in English
| WPRIM
| ID: wpr-84611
ABSTRACT
BACKGROUND AND PURPOSE:
Vascular shear stress is essential for maintaining the morphology and function of endothelial cells. We hypothesized that shear stress in the internal carotid artery (ICA) may differ between patients with ischemic stroke and healthy control subjects.METHODS:
ICA shear stress was calculated in 143 controls and 122 patients with ischemic stroke who had a normal ICA or an ICA with <50% stenosis. The stroke group included patients who presented with a first-ever or recurrent ischemic stroke but excluded cardioembolic stroke and uncertain etiologies. Of the 122 patients, 107 (87.7%) and 15 (12.3%) patients were categorized as first-ever and recurrent stroke, respectively.RESULTS:
Carotid diameters were significantly larger, and both peak-systolic and end-diastolic velocities were significantly lower in patients with ischemic stroke than in controls (all p values <0.05). Mean values of peak-systolic and end-diastolic shear stress in both ICAs were significantly lower in patients with ischemic stroke in models that adjusted for age, sex, and vascular risk factors (p for trend <0.05). The ICA shear stress was lowest in patients with recurrent stroke or the subtype of small-vessel occlusion. Higher peak-systolic and end-diastolic shear stresses in both ICAs were independently and negatively associated with ischemic stroke after adjusting for potential confounders (all p values <0.05).CONCLUSIONS:
ICA shear stresses were significantly lower in patients with ischemic stroke than in control subjects. Future studies should attempt to define the causal relationship between carotid arterial shear stress and ischemic stroke.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Carotid Arteries
/
Carotid Artery, Internal
/
Risk Factors
/
Constriction, Pathologic
/
Stroke
/
Endothelial Cells
/
Hemodynamics
Type of study:
Etiology study
/
Prognostic study
/
Risk factors
Limits:
Humans
Language:
English
Journal:
Journal of Clinical Neurology
Year:
2014
Type:
Article
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