Mechanism of Shenqi Jiangtang Granules in treatment of type 2 diabetes based on network pharmacology / 中草药

ABSTRACT

Objective: To explore the mechanism of Shenqi Jiangtang Granules in treatment of type 2 diabetes mellitus by network pharmacology. Methods: The active components and targets of Shenqi Jiangtang Granules and targets associated with type 2 diabetes were obtained by literature mining and database. Enrichr database was used to analyze gene ontology enrichment and Kyoto gene and genome encyclopedia. In addition, Cytoscape 3.5.1 software was used to draw network interaction diagrams, and imageGP tool was used to draw GO and KEGG bubble diagrams. Results: A total of 43 key active ingredients and 30 key targets were obtained. GO enrichment analysis included 918 items, including 56 cell component (CC) entries, 99 molecular function (MF) entries, and 763 biological process (BP) entries. CC entries were related to axonal membrane, nuclear transcription factor complex, RNA polymerase Ⅱ transcription factor complex, nuclear euchromatin, and platelet α granule. MF entries were mainly related to MAP kinase activity, vascular endothelial growth factor receptor binding and other aspects. BP entries were related to biological processes, mainly including angiogenesis, foam cell differentiation, and cellular response to interleukin-21. The KEGG pathway enrichment analysis included 105 KEGG pathways, which were closely related to IL-17 signaling pathway, AGE-RAGE signaling pathway in diabetic complications, VEGF signaling pathway, mitophagy and other signaling pathways. Conclusion: Shenqi Jiangtang Granules may play a role in treatment of type 2 diabetes by acting on neuroendocrine disorders, insulin resistance, oxidative stress, inflammation, and other related protein targets and pathways.