A new neo-clerodane diterpenoid from Salvia tiliifolia / 中草药

ABSTRACT

Objective: To study the chemical constituents of the aerial parts of Salvia tiliifolia. Methods: The compounds were isolated and purified by various modern chromatographies, and their structures were identified by spectroscopic data. Results: Two compounds were isolated from the acetone extract of the aerial parts of S. tiliifolia, which were elucidated as 1-(furan-3-yl)-8- (2-oxo- 2,5-dihydrofuran-3-yl)-1,7,8,9-tetrahydronaphtho[1,2-c]furan-3,6-dione (1) and dugesin B (2). Conclusion: Compound 1 is a new clerodane diterpene with no cytotoxicity, named as 1-keto-tilifodiolide.