Chemical constituents from stems and leaves of Aphanamixis sinensis and their antibacterial activities / 中草药
Chinese Traditional and Herbal Drugs
;
(24): 4614-4619, 2020.
Article
in Chinese
| WPRIM
| ID: wpr-846166
ABSTRACT
Objective:
To study the chemical constituents of stems and leaves from Aphanamixis sinensis and evaluate their antibacterial activities.Methods:
The compounds were isolated and purified by various column chromatography techniques, such as silica gel, ODS, Sephadex LH-20, and MCI, and their structures were identified by physiochemical properties and spectroscopic data. Moreover, antimicrobial activities against Staphylococcus aureus ATCC 25923, Escherichia coli CICC 10003, and Salmonella enterica UK-1 8956 of compounds 1-13 were evaluated by filter paper method.Results:
Fifteen compounds were isolated from A. polystachya which were elucidated as (23E)-25-methoxycycloart-23-en-3β-ol (1), 25-hydroxy-cycloart-23-en-3-one (2), 23 (Z)-9,19-cycloart-23-ene-3β,25-diol (3), 23 (E)-cycloart-23-en-3β,25-diol (4), ent-labd-8 (17), 13E-dien-15-ol (5), vulgaro (6), ambroxdiok (7), α-cadinol (8), 1 (10)-en-oxo-7α-isopropanoleremophilane (9), (5R,7R,10S)-isopterocarpolone (10), 1S,4S,5S,10R- 4,10-guaianediol (11), (4R,5R,7S,9S,10S)-(-)-eudesma-11 (13)-en-4,9-diol (12), phytol (13), ergosterol endoperoxide (14) and 7α-hydroxysitosterol (15).Conclusion:
All isolates were obtained from this plant for the first time, and compounds 2, 5, 7-10, and 12-15 were isolated from the genus Aphanamixis for the first time. Compound 5 showed obvious activity against S. aureus ATCC 25923 with the MIC value of 5 μg/mL.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Chinese Traditional and Herbal Drugs
Year:
2020
Type:
Article
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