Research progress on macrophage membrane nano-biomimetic preparations on brain diseases and its inspiration on druggability of active components of traditional Chinese medicine / 中草药

ABSTRACT

Although nano preparations could improve the physicochemical properties of drugs, they are easy to be recognized and cleared by mononuclear phagocytes, which will not only reduce the half-life of drugs, but also cause immunogen reaction, thus affecting the safe and effective use of drugs. The combination of cell membrane and new nanotechnology will increase the cell compatibility with the advantages of nano preparations, further enhance the targeting effect of target organs or tissues, and improve the efficacy. At present, the existence of the brain barrier restricts the entry of all macromolecular substances and 98% small molecule drugs into the brain, becoming the main problem in the treatment of encephalopathy. Macrophages are common immune cells and play an important role in the development and prognosis of brain diseases. Therefore, the combination of macrophage membranes and nano preparations becomes the immune system's own substances to avoid recognition and clearance, and increase the circulation of drugs, then reuse the blood-brain barrier permeability of macrophages to increase the drug into brains to improve the clinical efficacy. Traditional Chinese medicine has complex components and significant curative effect, but most of them have problems in poor solubility and stability, which lead to low bioavailability in vivo and affect the application. Therefore, based on domestic and foreign literatures, this article integrates the application of macrophage membrane modified nano-preparations in encephalopathy and its effects on the medicinal properties of active ingredients of traditional Chinese medicine, in order to promote the development and utilization of traditional Chinese medicine resources.