Primary research on components with anticomplement and antitussive activities from leave extracts of Chimonanthus nitens / 中草药
Chinese Traditional and Herbal Drugs
;
(24): 3869-3875, 2020.
Article
in Chinese
| WPRIM
| ID: wpr-846258
ABSTRACT
Objective:
To investigate and analyze anticomplement and antitussive activities and the active ingredients of the extract of Chimonanthus nitens leaf.Methods:
The classical anti-complement pathway and the concentrated ammonia-induced cough model was used to compare the activity of the different polar parts of C. nitens leaf, and the polar parts with anti-complement and antitussive activity were determined. A preliminary analysis of the chemical composition in activity extract was identified by high performance liquid chromatography-mass spectrometry. The main chemical components in the C. nitens leaf of antitussive and antibody activity were also evaluated.Results:
The ethyl acetate extract of C. nitens leaf had both anti-complement and antitussive effects. A total of 28 compounds were initially identified through mass spectrometry analysis. Kaempferol-3-O-rutinoside and kaempferol had both antitussive and anti-complement activities.Conclusion:
The ethyl acetate extract of C. nitens leaf has good anti-complement and antitussive activities, and the mainly active ingredients in it were kaempferol-3-O-rutinoside and kaempferol that could be used as quality-controlling chemical markers.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Chinese Traditional and Herbal Drugs
Year:
2020
Type:
Article
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