Innovation of pulvis modification technology in traditional Chinese medicine preparations: A case study of Shenling Baizhu Pulvis / 中草药

ABSTRACT

Objective: To study the powder properties and powder modification technology of Shenling Baizhu Pulvis (SBP), so as to lay a foundation for the study of the suitability of powder modification technology in the solid preparation of traditional Chinese medicine. Methods: The characterization and evaluation methods of powder in the field of materials science and pharmaceutical science were used for reference to evaluate the grouping of single medicinal materials in the particle design and the process rationality of composite particles. The preparation process of composite particles of SBP was optimized by L9(34) orthogonal test, and the surface properties of the composite particles were evaluated by SEM, IR and XRD. Results: The study on the powder properties of prescription raw materials showed that there was a good correlation between the grinding time and the particle size. Finally, the best process for composite particles was as following the pulverization temperature for powders of Ginseng Radix et Rhizoma, Dioscoreag Rhizoma, Nelumbinis Semen, Lablab Semen Album, Coicis Semen and Platycodonis Radix was -10 ℃ for 45 min, and then pulverization for another 4 min after adding with Atractylodis Macrocephalae Rhizoma, Poria, Amomi Fructus and Glycyrrhizae Radix et Rhizoma. The results showed that the composite particles were well formed and the preparation process was stable and feasible. Conclusion: The powder modification technology solves the powder defects in the preparation process of traditional powder, which provides experimental basis for powder modification technology to improve the quality of traditional Chinese medicine solid preparation and promote the development and upgrading of powder, pill and other traditional dosage forms.